Article
A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor.
Nature genetics - 1 Nov 1999
Madsen L S, Andersson E C, Jansson L, krogsgaard M, Andersen C B, Engberg J, Strominger J L, Svejgaard A, Hjorth J P, Holmdahl R, Wucherpfennig K W, Fugger L
Abstract excerpt
Multiple sclerosis (MS) is a complex chronic neurologic disease with a suspected autoimmune pathogenesis. Although there is evidence that the development of MS is determined by both environmental influences and genes, these factors are largely undefined, except for major histocompatibility (MHC) genes. Linkage analyses and association studies have shown that susceptibility to MS is associated with genes in the...
Topics
- Animals
- Autoantigens
- CD4 Antigens
- Central Nervous System
- DNA-Binding Proteins
- Disease Models, Animal
- Encephalitis
- Freund's Adjuvant
- Genes, Immunoglobulin
- Genetic Predisposition to Disease