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Article

Avoiding Drug Resistance in HIV Reverse Transcriptase.

Chemical reviews - 24 Mar 2021

Cilento Maria E, Kirby Karen A, Sarafianos Stefan G

Abstract excerpt

HIV reverse transcriptase (RT) is an enzyme that plays a major role in the replication cycle of HIV and has been a key target of anti-HIV drug development efforts. Because of the high genetic diversity of the virus, mutations in RT can impart resistance to various RT inhibitors. As the prevalence of drug resistance mutations is on the rise, it is necessary to design strategies that will lead to drugs less...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33507067
DOI: 10.1021/acs.chemrev.0c00967
PMCID: PMC8149104

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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