Drug Resistance, Virus Fitness and HIV-1 Mutagenesis

doi:10.2174/1381612043382404

Article

Drug Resistance, Virus Fitness and HIV-1 Mutagenesis

1 Dec 2004

Abstract excerpt

The evolution of antiretroviral drug resistance is a major problem in the treatment of human immunodeficiency virus type 1 (HIV-1) infection. Drug therapy failure is associated with accumulation of drug resistance mutations and results in the development of drug resistance. Drugs targeted against reverse transcriptase (RT) as well as drug-resistant RT have been shown to increase HIV-1 mutation frequencies....

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