Article
HIV-1 mutagenesis during antiretroviral therapy: implications for successful drug treatment.
Frontiers in bioscience : a journal and virtual library - 1 Jan 2005
Chen Renxiang, Quinones-Mateu Miguel E, Mansky Louis M
Abstract excerpt
The evolution of antiretroviral drug resistance is a major problem in the treatment of human immunodeficiency virus type 1 (HIV-1) infection. Drug therapy failure is associated with accumulation of mutations and results in the development of drug resistance. Drugs targeted against reverse transcriptase (RT) as well as drug-resistant RT have been shown to increase HIV-1 mutation frequencies. Furthermore,...
Topics
- Acquired Immunodeficiency Syndrome
- Animals
- Anti-Retroviral Agents
- Drug Resistance, Viral
- HIV
- HIV-1
- Humans
- Lentivirus
- Mutagenesis
- Mutagens
- Mutation
- RNA-Directed DNA Polymerase