Benign prostatic hyperplasia in a transgenic mouse: a new hormonally sensitive investigatory model.

doi:10.1016/s0022-5347(17)36169-4

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Article

Benign prostatic hyperplasia in a transgenic mouse: a new hormonally sensitive investigatory model.

The Journal of urology - 1 Mar 1993

Tutrone R F, Ball R A, Ornitz D M, Leder P, Richie J P

Abstract excerpt

Recent advances in molecular biology have enabled incorporation of proto-oncogenes into the mouse germline. In this study we use a transgenic mouse line that overexpresses the fibroblastic growth factor (FGF) family member, int-2, under the control of mouse mammary tumor virus (MMTV) regulatory elements. One of the tissues targeted by MMTV is the mouse prostate. Expression of the MMTV-int-2 transgene in male...

Topics

5-alpha Reductase Inhibitors
Androstenes
Animals
Azasteroids
Dihydrotestosterone
Disease Models, Animal
Fibroblast Growth Factor 3
Fibroblast Growth Factors
Finasteride
Flutamide
Genes, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mammary Tumor Virus, Mouse

Mice

Mice, Transgenic

Orchiectomy

Phenotype

Prostate

Source

Open in PubMed

Identifiers

PMID: 7679760
DOI: 10.1016/s0022-5347(17)36169-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7679760-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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