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Article

Benign prostatic hyperplasia in a transgenic mouse: a new hormonally sensitive investigatory model.

The Journal of urology - 1 Mar 1993

Tutrone R F, Ball R A, Ornitz D M, Leder P, Richie J P

Abstract excerpt

Recent advances in molecular biology have enabled incorporation of proto-oncogenes into the mouse germline. In this study we use a transgenic mouse line that overexpresses the fibroblastic growth factor (FGF) family member, int-2, under the control of mouse mammary tumor virus (MMTV) regulatory elements. One of the tissues targeted by MMTV is the mouse prostate. Expression of the MMTV-int-2 transgene in male...

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Identifiers

PMID: 7679760
DOI: 10.1016/s0022-5347(17)36169-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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