Article
Enlargement of the ampullary gland and seminal vesicle, but not the prostate in int-2/Fgf-3 transgenic mice.
Differentiation; research in biological diversity - 1 Mar 1998
Donjacour A A, Thomson A A, Cunha G R
Abstract excerpt
Expression of the int2/Fgf-3 gene occurs during normal embryonic development and is associated with mammary cancer in mice. Overexpression of this gene under the control of the mouse mammary tumor virus long terminal repeat (MMTV-LTR) in males was reported to result in prostatic enlargement. In t...
Topics
- Animals
- Disease Models, Animal
- Evaluation Studies as Topic
- Female
- Gene Expression Regulation, Developmental
- Gene Expression Regulation, Neoplastic
- Hypertrophy
- Male
- Mice
- Mice, Transgenic
- Organ Size
- Phenotype
- Prostatic Hyperplasia
- Seminal Vesicles
- Testis
- Urogenital System
- Vas Deferens