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Article

Disruption of growth hormone signaling retards prostate carcinogenesis in the Probasin/TAg rat.

Endocrinology - 1 Mar 2008

Wang Zhuohua, Luque Raul M, Kineman Rhonda D, Ray Vera H, Christov Konstantin T, Lantvit Daniel D, Shirai Tomoyuki, Hedayat Samad, Unterman Terry G, Bosland Maarten C, Prins Gail S, Swanson Steven M

Abstract excerpt

We asked whether down-regulation of GH signaling could block carcinogenesis in the Probasin/TAg rat, a model of aggressive prostate cancer. The Spontaneous Dwarf rat, which lacks GH due to a mutation (dr) in its GH gene, was crossed with the Probasin/TAg rat, which develops prostate carcinomas at 100% incidence by 15 wk of age. Progeny were heterozygous for the TAg oncogene and homozygous for either the wild-type...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18079205
DOI: 10.1210/en.2007-1410
PMCID: PMC2275369

Genes

GHR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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