Article
Age-dependent histopathological findings in the prostate of probasin/SV40 T antigen transgenic rats: lack of influence of carcinogen or testosterone treatment.
Cancer science - 1 Feb 2003
Cho Young-Man, Takahashi Satoru, Asamoto Makoto, Suzuki Shugo, Inaguma Shingo, Hokaiwado Naomi, Shirai Tomoyuki
Abstract excerpt
Sequential changes in the phenotype of prostatic lesions and the impact of additional carcinogen treatment or castration on development and progression of prostate cancers were examined in probasin/simian virus 40 (SV40) T antigen transgenic (TG) rats. Non-invasive prostate adenocarcinomas were evident in all lobes at 15 weeks of age. Invasive tumors were limited to the anterior lobe at this time point and were...
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