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Article

A transgenic mouse model of metastatic prostate cancer originating from neuroendocrine cells

22 Dec 1998

Abstract excerpt

A transgenic mouse model of metastatic prostate cancer has been developed that is 100% penetrant in multiple pedigrees. Nucleotides -6500 to +34 of the mouse cryptdin-2 gene were used to direct expression of simian virus 40 T antigen to a subset of neuroendocrine cells in all lobes of the FVB/N mouse prostate. Transgene expression is initiated between 7 and 8 weeks of age and leads to development of prostatic...

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PMID: 9860977
DOI: 10.1073/pnas.95.26.15382

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