Article
In vivo mutations at the H-2 locus in mouse lymphocytes.
Mutation research - 1 Jan 1993
Dempsey J L, Odagiri Y, Morley A A
Abstract excerpt
An experimental system has been developed to study in vivo autosomal mutations in murine splenic lymphocytes. Mutant lymphocytes were isolated by immunocytotoxicity using monoclonal antibodies directed against the k and d alleles of the K and D H-2 histocompatibility loci and were enumerated using limiting-dilution cloning. Genomic allele loss in mutant clones was detected using allele-specific primers in a...
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