Article
Mutant frequency at the H-2K class 1 and HPRT genes in T lymphocytes from the X-ray-exposed mouse.
International journal of radiation biology - 1 Apr 1995
Klarmann B, Wixler V, Lorenz R, Hempel K
Abstract excerpt
The frequency of H-2Kk and HPRT-deficient T cells was measured in the H-2Kb, kDd,k genotype mouse 8-10 weeks after X-ray exposure at doses up to 6 Gy to compare the mutant frequency (MF) of an autosomal gene with that of an X-chromosomal gene. H-2K mutants were enriched by magnetic cell separatio...
Topics
- Animals
- Female
- Genes, MHC Class I
- H-2 Antigens
- Hypoxanthine Phosphoribosyltransferase
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Mutation
- Spleen
- T-Lymphocytes