Article
Recognition of a highly conserved region of human immunodeficiency virus type 1 gp120 by an HLA-Cw4-restricted cytotoxic T-lymphocyte clone.
Journal of virology - 1 Jan 1993
Johnson R P, Trocha A, Buchanan T M, Walker B D
Abstract excerpt
Human immunodeficiency virus type 1 (HIV-1) isolates exhibit extensive sequence variation, particularly in the gp120 subunit of the envelope glycoprotein, and the degree of this variation has raised questions as to whether conserved regions of the HIV-1 envelope can be recognized by the host immu...
Topics
- Amino Acid Sequence
- Antibody Specificity
- CD8 Antigens
- Clone Cells
- Conserved Sequence
- DNA Mutational Analysis
- Epitopes
- Genetic Variation
- HIV Envelope Protein gp120
- HIV Seropositivity
- HIV-1
- HLA-C Antigens
- Humans
- Molecular Sequence Data
- Oligopeptides