Mutation of human immunodeficiency virus type 1 at amino acid 585 on gp41 results in loss of killing by CD8+ A24-restricted cytotoxic T lymphocytes.

doi:10.1128/JVI.66.5.3151-3154.1992

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Article

Mutation of human immunodeficiency virus type 1 at amino acid 585 on gp41 results in loss of killing by CD8+ A24-restricted cytotoxic T lymphocytes.

Journal of virology - 1 May 1992

Dai L C, West K, Littaua R, Takahashi K, Ennis F A

Abstract excerpt

A human leukocyte antigen A24-restricted CD8+ cytotoxic T-cell clone specific for gp41 of human immunodeficiency virus type 1 was isolated from an infected individual. The epitope was localized to amino acids 584 to 591 (YLKDQQLL, NL43 env sequence) of gp41 by using a panel of recombinant vaccini...

Topics

Amino Acid Sequence
Antigens, Differentiation
B-Lymphocytes
CD8 Antigens
Clone Cells
Cytotoxicity, Immunologic
Epitopes
Genetic Vectors
HIV Envelope Protein gp41
HIV-1
HLA-A Antigens
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Peptide Fragments

Stem Cells

T-Lymphocytes, Cytotoxic

Vaccinia virus

Source

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Identifiers

PMID: 1373204
DOI: 10.1128/JVI.66.5.3151-3154.1992
PMCID: PMC241078

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1373204-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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