Article
[Tumor suppressor genes: mutations in RB and p53 genes are significant carcinogenic factors].
Lakartidningen - 23 Sept 1992
Wiman K G
Abstract excerpt
The RB and p53 tumour suppressor genes encode nuclear proteins that exert an inhibitive effect on cell growth. A large variety of human tumour types manifest loss or mutation of the RB or p53 genes, and p53 mutation is the commonest genetic alteration found in tumour cells. In addition, the RB and p53 proteins may be inactivated by complex formation with viral oncoproteins--for instance, in the case of cervical...
Topics
- Genes, Retinoblastoma
- Genes, p53
- Humans
- Mutation
- Neoplasms
- Oncogene Proteins, Viral
- Retinoblastoma Protein