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Article

Dominant negative MYC blocks transformation by ABL oncogenes.

Cell - 18 Sept 1992

Sawyers C L, Callahan W, Witte O N

Abstract excerpt

A link between ABL oncogenes and MYC is suggested by the transformation synergy that is observed when MYC is expressed at high levels. Dominant negative MYC proteins were overexpressed in fibroblasts to determine if MYC complements ABL oncogene transformation or is essential for this process. Transformation by both v-abl and BCR-ABL oncogenes was reduced 5- to 10-fold, whereas transformation by the...

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Source

Identifiers

PMID: 1525828
DOI: 10.1016/0092-8674(92)90241-4

Genes

MYC
BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Dominant negative MYC blocks transformation by ABL oncogenes.PMID 1525828Read ↗

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