Dominant negative MYC blocks transformation by ABL oncogenes.

doi:10.1016/0092-8674(92)90241-4

Back to search

Article

Dominant negative MYC blocks transformation by ABL oncogenes.

Cell - 18 Sept 1992

Sawyers C L, Callahan W, Witte O N

Abstract excerpt

A link between ABL oncogenes and MYC is suggested by the transformation synergy that is observed when MYC is expressed at high levels. Dominant negative MYC proteins were overexpressed in fibroblasts to determine if MYC complements ABL oncogene transformation or is essential for this process. Tra...

Topics

Animals
Bone Marrow
Cell Transformation, Neoplastic
Cells, Cultured
Fibroblasts
Genes, Dominant
Genes, abl
Genes, mos
Genes, myc
Leucine Zippers
Mice
Mice, Inbred BALB C
Mutation
Rats
Structure-Activity Relationship
Suppression, Genetic

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.