Article
Constitutive activation of c-Jun N-terminal kinase by a mutant epidermal growth factor receptor.
The Journal of biological chemistry - 30 Jan 1998
Antonyak M A, Moscatello D K, Wong A J
Abstract excerpt
Epidermal growth factor receptor (EGF) variant type III (EGFRvIII) is a constitutively active, naturally occurring mutation of the EGF receptor that is found in many types of human tumors. When overexpressed in NIH3T3 fibroblasts, EGFRvIII induces transformation by enhancing cell growth and reduc...
Topics
- 3T3 Cells
- Animals
- Apoptosis
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Transformation, Neoplastic
- Down-Regulation
- Enzyme Activation
- ErbB Receptors
- Humans
- JNK Mitogen-Activated Protein Kinases
- Mice
- Mitogen-Activated Protein Kinases
- Mutation
- Nitriles
- Phosphoinositide-3 Kinase Inhibitors
- Protein Tyrosine Phosphatases
- Quinazolines
- Signal Transduction