Stunted morphologies of cerebellar Purkinje cells in lurcher and staggerer mice are cell-intrinsic effects of the mutant genes.

Abstract excerpt

Purkinje cells in the neurological mutants lurcher and staggerer exhibit a number of abnormal properties; mutant<==>wild-type chimeras have shown that these properties are direct effects of the mutant gene. What has remained unexplored are the numerous dendritic abnormalities that the two mutant Purkinje cells exhibit. In staggerer, Purkinje cells have rudimentary, unbranched dendrites that lack tertiary...

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