The Lurcher cerebellar mutant phenotype is not expressed on a staggerer mutant background.

Abstract excerpt

The hierarchy of the various processes responsible for the development of the complex, elaborated Purkinje cell can be examined by taking advantage of a series of spontaneous mutations that affect cerebellar development in the mouse. This study uses double mutants containing genes for two separate hereditary cerebellar mutations that have been shown to act intrinsically in Purkinje cells in order to investigate...

Topics

• Animals
• Behavior, Animal
• Cerebellum
• Gene Expression
• Immunohistochemistry
• Mice
• Mice, Neurologic Mutants
• Pedigree
• Phenotype