Article
The Spontaneous Ataxic Mouse Mutant Tippy is Characterized by a Novel Purkinje Cell Morphogenesis and Degeneration Phenotype.
Cerebellum (London, England) - 1 Jun 2015
Shih Evelyn K, Sekerková Gabriella, Ohtsuki Gen, Aldinger Kimberly A, Chizhikov Victor V, Hansel Christian, Mugnaini Enrico, Millen Kathleen J
Abstract excerpt
This study represents the first detailed analysis of the spontaneous neurological mouse mutant, tippy, uncovering its unique cerebellar phenotype. Homozygous tippy mutant mice are small, ataxic, and die around weaning. Although the cerebellum shows grossly normal foliation, tippy mutants display a complex cerebellar Purkinje cell phenotype consisting of abnormal dendritic branching with immature spine features...
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