Cell loss in the inferior olive of the staggerer mutant mouse is an indirect effect of the gene.

doi:10.3109/01677069009107113

Back to search

Article

Cell loss in the inferior olive of the staggerer mutant mouse is an indirect effect of the gene.

Journal of neurogenetics - 1 Aug 1990

Zanjani H S, Mariani J, Herrup K

Abstract excerpt

Staggerer (sg) is an autosomal recessive mutation in mouse that causes severe cerebellar atrophy. In this mutant, the Purkinje cell (PC) number is reduced by about 75% and the remaining Purkinje cells have a reduced dendritic arbor and an ectopic location. Previous analysis of staggerer chimeras...

Topics

Animals
Cell Count
Chimera
Genes, Recessive
Mice
Mice, Neurologic Mutants
Olivary Nucleus
Phenotype

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.