The lurcher gene induces apoptotic death in cerebellar Purkinje cells.

doi:10.1242/dev.121.4.1183

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

The lurcher gene induces apoptotic death in cerebellar Purkinje cells.

Development (Cambridge, England) - 1 Apr 1995

Norman D J, Feng L, Cheng S S, Gubbay J, Chan E, Heintz N

Abstract excerpt

In the neurologically mutant mouse strain lurcher (Lc), heterozygous animals display cell autonomous degeneration of cerebellar Purkinje cells beginning in the second postnatal week. During the course of our studies to identify the genetic lesion responsible for this disease (Norman et al., 1991), we have formulated an hypothesis suggesting that in Lc Purkinje cells homeostasis is sufficiently perturbed to lead...

Topics

Animals
Apoptosis
Blotting, Southern
Clusterin
Gait
Gene Expression
Genotype
Glycoproteins
Immunohistochemistry
In Situ Hybridization
Mice
Mice, Mutant Strains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microscopy, Electron

Molecular Chaperones

Nerve Tissue Proteins

Polymorphism, Restriction Fragment Length

Purkinje Cells

RNA, Messenger

Source

Open in PubMed

Identifiers

PMID: 7743930
DOI: 10.1242/dev.121.4.1183

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7743930-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The lurcher gene induces apoptotic death in cerebellar Purkinje cells.PMID 7743930Read ↗

Lurcher Purkinje cells express glutamic acid decarboxylase and calbindin mRNAs.Semantic proximity Read ↗

The lurcher mutation and ionotropic glutamate receptors: contributions to programmed neuronal death in vivo.Semantic proximity Read ↗

Death and survival of heterozygous Lurcher Purkinje cells in vitro.Semantic proximity Read ↗

Purkinje cell death: Differences between developmental cell death and neurodegenerative death in mutant miceSemantic proximity Read ↗

Induction of neuronal cell death by paraneoplastic Ma1 antigenSemantic proximity Read ↗

The Lurcher mouse: fresh insights from an old mutant.Semantic proximity Read ↗

The Lurcher cerebellar mutant phenotype is not expressed on a staggerer mutant background.Semantic proximity Read ↗

Cell death during development of testis and cerebellum in the mutant mouse weaver.Semantic proximity Read ↗

Fluoro-jade identification of cerebellar granule cell and purkinje cell death in the alpha1A calcium ion channel mutant mouse, leaner.Semantic proximity Read ↗

Loss of Elp1 in cerebellar granule cell progenitors models ataxia phenotype of Familial Dysautonomia.Semantic proximity Read ↗

Generation of a high-resolution genetic map and a YAC contig of the Lurcher locus on mouse chromosome 6.Semantic proximity Read ↗

Loss of the Familial Dysautonomia gene <i>Elp1</i> in cerebellar granule cell progenitors leads to ataxia in miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.