Article
Fluoro-jade identification of cerebellar granule cell and purkinje cell death in the alpha1A calcium ion channel mutant mouse, leaner.
Neuroscience - 1 Jan 2003
Frank T C, Nunley M C, Sons H D, Ramon R, Abbott L C
Abstract excerpt
Cell death is a critical component of normal nervous system development; too little or too much results in abnormal development and function of the nervous system. The leaner mouse exhibits excessive, abnormal cerebellar granule cell and Purkinje cell death during postnatal development, which is a consequence of a mutated calcium ion channel subunit, alpha(1A). Previous studies have shown that leaner cerebellar...
Topics
- Animals
- Calcium Channels
- Calcium Channels, N-Type
- Calcium Channels, P-Type
- Calcium Channels, Q-Type
- Cell Death
- Cerebellar Diseases
- Cerebellum
- Female
- Fluoresceins
- Fluorescent Dyes
- Immunohistochemistry
- In Situ Nick-End Labeling
- Male