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Article

Evidence that insulin is imprinted in the human yolk sac.

Diabetes - 1 Jan 2001

Moore G E, Abu-Amero S N, Bell G, Wakeling E L, Kingsnorth A, Stanier P, Jauniaux E, Bennett S T

Abstract excerpt

Allelic variation in the size of the insulin (INS) variable number tandem repeat (VNTR) correlates with the expression of both INS in the pancreas and thymus and IGF2 (the gene downstream of INS) in the placenta. In addition, the shorter, class I alleles are associated with type 1 diabetes, whereas the longer, class III alleles are associated with type 2 diabetes, polycystic ovary syndrome (PCOS), and size at...

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Source

Identifiers

PMID: 11147788
DOI: 10.2337/diabetes.50.1.199

Genes

INS
IGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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