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Article

Large parental differences in chromatin organization in pancreatic beta cell line explaining diabetes susceptibility effects.

Nature communications - 15 Jul 2021

Jian Xing, Felsenfeld Gary

Abstract excerpt

Previous GWAS studies identified non-coding loci with parent-of-origin-specific effects on Type 2 diabetes susceptibility. Here we report the molecular basis for one such locus near the KRTAP5-6 gene on chromosome 11. We determine the pattern of long-range contacts between an enhancer in this locus and the human INS promoter 460 kb away, in the human pancreatic β-cell line, EndoC-βH1. 3C long range contact...

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Identifiers

PMID: 34267199
DOI: 10.1038/s41467-021-24635-2
PMCID: PMC8282625

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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