Article
IGF2 is parentally imprinted during human embryogenesis and in the Beckwith-Wiedemann syndrome.
Nature genetics - 1 May 1993
Ohlsson R, Nyström A, Pfeifer-Ohlsson S, Töhönen V, Hedborg F, Schofield P, Flam F, Ekström T J
Abstract excerpt
The phenomenon of parental imprinting involves the preferential expression of one parental allele of a subset of chromosomal genes and has so far only been documented in the mouse. We show here, by exploiting sequence polymorphisms in exon nine of the human insulin-like growth factor 2 (IGF2) gen...
Topics
- Alleles
- Animals
- Base Sequence
- Beckwith-Wiedemann Syndrome
- Embryonic and Fetal Development
- Gene Expression Regulation
- Insulin-Like Growth Factor II
- Mice
- Molecular Sequence Data
- Parents
- Polymerase Chain Reaction