High allele loss rates at 17q12-q21 in breast and ovarian tumors from BRCAl-linked families. The Breast Cancer Linkage Consortium.

doi:10.1002/gcc.2870130310

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Article

High allele loss rates at 17q12-q21 in breast and ovarian tumors from BRCAl-linked families. The Breast Cancer Linkage Consortium.

Genes, chromosomes & cancer - 1 Jul 1995

Cornelis R S, Neuhausen S L, Johansson O, Arason A, Kelsell D, Ponder B A, Tonin P, Hamann U, Lindblom A, Lalle P

Abstract excerpt

Loss of heterozygosity (LOH) was evaluated in 174 breast and ovarian tumors derived from 94 families with at least 3 first-degree relatives affected with either of these cancers. By linkage analysis 26 families were identified as having a high posterior probability of being due to BRCAl (the brea...

Topics

Alleles
BRCA1 Protein
Breast Neoplasms
Chromosome Mapping
Chromosomes, Human, Pair 17
Female
Genetic Linkage
Heterozygote
Humans
Lod Score
Mutation
Neoplasm Proteins
Ovarian Neoplasms
Pedigree
Transcription Factors

Source

Open in PubMed

Identifiers

PMID: 7669740
DOI: 10.1002/gcc.2870130310

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7669740-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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