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Article

High allele loss rates at 17q12-q21 in breast and ovarian tumors from BRCAl-linked families. The Breast Cancer Linkage Consortium.

Genes, chromosomes & cancer - 1 Jul 1995

Cornelis R S, Neuhausen S L, Johansson O, Arason A, Kelsell D, Ponder B A, Tonin P, Hamann U, Lindblom A, Lalle P

Abstract excerpt

Loss of heterozygosity (LOH) was evaluated in 174 breast and ovarian tumors derived from 94 families with at least 3 first-degree relatives affected with either of these cancers. By linkage analysis 26 families were identified as having a high posterior probability of being due to BRCAl (the breast/ovarian cancer susceptibility locus on 17q12-21) with lod scores varying from 0.51 to 9.49. Tumor genotypes were...

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PMID: 7669740
DOI: 10.1002/gcc.2870130310

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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