Tumor necrosis factor (TNF) and TNFR1 polymorphisms are not risk factors for rheumatoid arthritis in a Mexican population.

doi:10.1007/s11033-018-4155-2

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Article

Tumor necrosis factor (TNF) and TNFR1 polymorphisms are not risk factors for rheumatoid arthritis in a Mexican population.

Molecular biology reports - 1 Jun 2018

Cadena-Sandoval Daniel, Alemán-Ávila Isidro, Barbosa-Cobos Rosa Elda, Becerril-Mendoza Lizbeth Teresa, Fragoso José Manuel, Ramírez-Bello Julián

Abstract excerpt

Tumor necrosis factor (TNF) plays an important role in the pathogenesis of rheumatoid arthritis (RA). Different genetic variants including the TNF -308G/A polymorphism are associated with RA susceptibility. However, these findings have not been replicated in all populations. The aim of this study was to determine whether the TNF -1031T/C (rs1799964), -376G/A (rs1800750), -308G/A (rs1800629) -238G/A (rs361525),...

Topics

Adult
Aged
Alleles
Arthritis, Rheumatoid

Source

Open in PubMed

Identifiers

PMID: 29404828
DOI: 10.1007/s11033-018-4155-2

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Case-Control Studies

Female

Gene Frequency

Genetic Predisposition to Disease

Genotype

Humans

Male

Mexico

Middle Aged

Polymorphism, Single Nucleotide

Promoter Regions, Genetic

Receptors, Tumor Necrosis Factor, Type I

Risk Factors

Tumor Necrosis Factor-alpha