Article
TNF-alpha -308 promoter polymorphism in patients with rheumatoid arthritis.
Scandinavian journal of rheumatology - 1 Jan 2005
Pawlik A, Florczak M, Ostanek L, Brzosko M, Brzosko I, Szklarz B Gawronska
Abstract excerpt
OBJECTIVES: Rheumatoid arthritis (RA) is a chronic inflammatory disease in which tumour necrosis factor-alpha (TNF-alpha) plays an important role. There are, however, controversial reports that TNF-alpha promoter polymorphism may be an independent marker of susceptibility and severity of RA. The aim of the present study was to examine the TNF-alpha -308 promoter polymorphism in patients with RA. METHODS: We...
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