Article
Genetic variants in toll-like receptors are not associated with rheumatoid arthritis susceptibility or anti-tumour necrosis factor treatment outcome.
PloS one - 15 Dec 2010
Coenen Marieke J H, Enevold Christian, Barrera Pilar, Schijvenaars Mascha M V A P, Toonen Erik J M, Scheffer Hans, Padyukov Leonid, Kastbom Alf, Klareskog Lars, Barton Anne, Kievit Wietske, Rood Maarten J, Jansen Tim L, Swinkels Dorine, van Riel Piet L C M, Franke Barbara, Bendtzen Klaus, Radstake Timothy R D J
Abstract excerpt
BACKGROUND: Several studies point to a role of Toll-like receptors (TLRs) in the development of rheumatoid arthritis (RA). We investigated if genetic variants in TLR genes are associated with RA and response to tumour necrosis factor blocking (anti-TNF) medication. METHODOLOGY AND PRINCIPAL FINDINGS: 22 single nucleotide polymorphisms (SNPs) in seven TLR genes were genotyped in a Dutch cohort consisting of 378 RA...
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