Modeling and optimization of populations subject to time-dependent mutation.

doi:10.1073/pnas.92.18.8219

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Article

Modeling and optimization of populations subject to time-dependent mutation.

Proceedings of the National Academy of Sciences of the United States of America - 29 Aug 1995

Kepler T B, Perelson A S

Abstract excerpt

It has become clear that many organisms possess the ability to regulate their mutation rate in response to environmental conditions. So the question of finding an optimal mutation rate must be replaced by that of finding an optimal mutation schedule. We show that this task cannot be accomplished...

Topics

B-Lymphocytes
Genetics, Population
Models, Genetic
Monte Carlo Method
Mutation

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