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Article

Tuning environmental timescales to evolve and maintain generalists.

Proceedings of the National Academy of Sciences of the United States of America - 9 Jun 2020

Sachdeva Vedant, Husain Kabir, Sheng Jiming, Wang Shenshen, Murugan Arvind

Abstract excerpt

Natural environments can present diverse challenges, but some genotypes remain fit across many environments. Such "generalists" can be hard to evolve, outcompeted by specialists fitter in any particular environment. Here, inspired by the search for broadly neutralizing antibodies during B cell affinity maturation, we demonstrate that environmental changes on an intermediate timescale can reliably evolve...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32457160
DOI: 10.1073/pnas.1914586117
PMCID: PMC7293598

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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