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Article

The metastatic microenvironment: Brain-derived soluble factors alter the malignant phenotype of cutaneous and brain-metastasizing melanoma cells.

International journal of cancer - 1 Dec 2012

Klein Anat, Sagi-Assif Orit, Izraely Sivan, Meshel Tsipi, Pasmanik-Chor Metsada, Nahmias Clara, Couraud Pierre-Olivier, Erez Neta, Hoon Dave S B, Witz Isaac P

Abstract excerpt

The working hypothesis of this study is that the interactions between the brain microenvironment and melanoma cells determine metastasis formation at this organ site. The aim of the study was to evaluate the contribution of such interactions to the formation of brain metastasis in nude mice xenografted with human melanoma cells. An insight into these interactions is an essential prerequisite for the development...

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Source

Identifiers

PMID: 22447293
DOI: 10.1002/ijc.27552

Genes

CCR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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