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Article

Lack of evidence of phenotypic complementation of E1A/E1B-deleted adenovirus type 5 upon superinfection by wild-type virus in the cotton rat.

Journal of virology - 1 Oct 1995

Oualikene W, Gonin P, Eloit M

Abstract excerpt

The safety of replication-defective viruses used as vectors is based on the deletion of essential gene(s). Adenovirus vector safety relies on the deletion of the E1A/E1B region. This region encodes the immediate-early proteins that trans activate all other early regions, so DNA replication in these deletion mutants is dramatically reduced. We have previously shown that E1A deletion is efficient in vivo and...

Topics

Adenoviridae Infections
Adenovirus E1A Proteins
Adenovirus E1B Proteins
Adenoviruses, Human
Animals
Cell Line
Defective Viruses
Gene Deletion
Genetic Complementation Test
Humans
Nasal Mucosa

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Recombination, Genetic

Sigmodontinae

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 7666553
DOI: 10.1128/JVI.69.10.6518-6524.1995
PMCID: PMC189553

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7666553-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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