Allelic associations and homozygosity at loci from HLA-B to D6S299 in genetic haemochromatosis.

doi:10.1136/jmg.32.6.446

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Article

Allelic associations and homozygosity at loci from HLA-B to D6S299 in genetic haemochromatosis.

Journal of medical genetics - 1 Jun 1995

Raha-Chowdhury R, Bowen D J, Burnett A K, Worwood M

Abstract excerpt

Haemochromatosis (GH) is an autosomal recessive disorder in which increased iron absorption causes iron overload. The gene (HFE) is closely linked to HLA-A on chromosome 6 (6p21.3) but has not yet been identified. We have examined eight polymorphic loci, HLA-B (most centromeric), I82, D6S265, HLA...

Topics

Adolescent
Adult
Alleles
Chromosome Mapping
Chromosomes, Human, Pair 6
Female
Genes, Dominant
Genetic Linkage
HLA-B Antigens
Haplotypes
Hemochromatosis
Homozygote
Humans
Male
Middle Aged
Pedigree

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