HFE genotypes and haemochromatosis: quantifying the risks of disease.

Abstract excerpt

Hereditary haemochromatosis (HH) is an autosomal recessive disease involving mutations in the recently characterised HFE gene linked to HLA-A in the major histocompatibility complex. The known HFE polymorphisms include the wild-type allele, a G-->A substitution at base 845 (845A) and a C-->G substitution at position 187 (187G). Although most cases of HH are accountable by homozygosity of the 845A allele the exact...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Genetic Linkage
• Share to Genotype
• Share to Hemochromatosis