Article
Analysis of HLA-A antigens and C282Y and H63D mutations of the HFE gene in Brazilian patients with hemochromatosis.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 1 Mar 2002
Bittencourt P L, Palácios S A, Couto C A, Cançado E L R, Carrilho F J, Laudanna A A, Kalil J, Gayotto L C C, Goldberg A C
Abstract excerpt
The hemochromatosis gene, HFE, is located on chromosome 6 in close proximity to the HLA-A locus. Most Caucasian patients with hereditary hemochromatosis (HH) are homozygous for HLA-A3 and for the C282Y mutation of the HFE gene, while a minority are compound heterozygotes for C282Y and H63D. The prevalence of these mutations in non-Caucasian patients with HH is lower than expected. The objective of the present...
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