New polymorphic microsatellite markers place the haemochromatosis gene telomeric to D6S105.

doi:10.1093/hmg/4.10.1869

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Article

New polymorphic microsatellite markers place the haemochromatosis gene telomeric to D6S105.

Human molecular genetics - 1 Oct 1995

Raha-Chowdhury R, Bowen D J, Stone C, Pointon J J, Terwilliger J D, Shearman J D, Robson K J, Bomford A, Worwood M

Abstract excerpt

The haemochromatosis gene (HFE) is linked to both HLA-A and D6S105 on the short arm of chromosome 6 but these markers are separated by approximately 2 Mb of DNA. Most chromosomes carrying HFE have a common haplotype which extends from HLA-A to D6S105 and includes HLA-F. To localise the gene more precisely we have examined 10 microsatellite markers extending over a genetic distance of approximately 5 cM from...

Topics

Alleles
Australia
Chromosome Mapping
Chromosomes, Human, Pair 6
DNA, Satellite
Female
Gene Frequency
Genetic Linkage
Genetic Markers
HLA-A Antigens
Haplotypes
Hemochromatosis
Humans
Linkage Disequilibrium

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Open in PubMed

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PMID: 8595409
DOI: 10.1093/hmg/4.10.1869

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Male

Pedigree

Polymorphism, Genetic

Probability