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Article

HFE codon 63/282 (H63D/C282Y) dimorphism in German patients with genetic hemochromatosis.

Tissue antigens - 1 Mar 1998

Gottschalk R, Seidl C, Löffler T, Seifried E, Hoelzer D, Kaltwasser J P

Abstract excerpt

Genetic hemochromatosis (GH) is closely associated with genes of the major histocompatibility complex (MHC) on chromosome 6. Recently, a candidate gene for GH, with structural similarities to MHC class I genes, designated HLA-H and presently named HFE, has been cloned. The HFE gene is localized telomeric to the MHC and several reports have indicated that the HFE gene is mutated in GH patients. In the present...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9550327
DOI: 10.1111/j.1399-0039.1998.tb03101.x

Genes

HFE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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HFE codon 63/282 (H63D/C282Y) dimorphism in German patients with genetic hemochromatosis.PMID 9550327Read ↗

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Haemochromatosis in the new millennium.Semantic proximity Read ↗

Low penetrant hemochromatosis phenotype in eight families: no evidence of modifiers in the MHC region.Semantic proximity Read ↗

[From gene to disease; HFE-mutations in primary haemochromatosis].Semantic proximity Read ↗

HFE, the MHC and hemochromatosis: paradigm for an extended function for MHC class I.Semantic proximity Read ↗

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Heterozygosity for the C282Y mutation in the hemochromatosis gene is associated with increased serum iron, transferrin saturation, and hemoglobin in young women: a protective role against iron deficiency?Semantic proximity Read ↗

HLA-A*03, the hemochromatosis ancestral haplotype, and phenotypes of referred hemochromatosis probands with HFE p.C282Y homozygosity.Semantic proximity Read ↗

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