Article
HFE codon 63/282 (H63D/C282Y) dimorphism in German patients with genetic hemochromatosis.
Tissue antigens - 1 Mar 1998
Gottschalk R, Seidl C, Löffler T, Seifried E, Hoelzer D, Kaltwasser J P
Abstract excerpt
Genetic hemochromatosis (GH) is closely associated with genes of the major histocompatibility complex (MHC) on chromosome 6. Recently, a candidate gene for GH, with structural similarities to MHC class I genes, designated HLA-H and presently named HFE, has been cloned. The HFE gene is localized t...
Topics
- Aspartic Acid
- Codon
- Cysteine
- Female
- Genotype
- Germany
- HLA Antigens
- Hemochromatosis
- Hemochromatosis Protein
- Histidine
- Histocompatibility Antigens Class I
- Humans
- Male
- Membrane Proteins
- Point Mutation
- Polymorphism, Genetic
- Tyrosine