Article
A study of 82 extended HLA haplotypes in HFE-C282Y homozygous hemochromatosis subjects: relationship to the genetic control of CD8+ T-lymphocyte numbers and severity of iron overload.
BMC medical genetics - 1 Mar 2006
Cruz Eugénia, Vieira Jorge, Almeida Susana, Lacerda Rosa, Gartner Andrea, Cardoso Carla S, Alves Helena, Porto Graça
Abstract excerpt
BACKGROUND: It has been recently demonstrated that CD8+ T-lymphocyte numbers are genetically transmitted in association with the MHC class I region. The present study was designed with the objective of narrowing the region associated with the setting of CD8+ T-lymphocyte numbers in a population of C282Y homozygous hemochromatosis subjects, in whom a high prevalence of abnormally low CD8+ T-lymphocyte counts has...
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