Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Overexpression of TEAD-1 in transgenic mouse striated muscles produces a slower skeletal muscle contractile phenotype.

The Journal of biological chemistry - 26 Dec 2008

Tsika Richard W, Schramm Christine, Simmer Gretchen, Fitzsimons Daniel P, Moss Richard L, Ji Juan

Abstract excerpt

TEA domain (TEAD) transcription factors serve important functional roles during embryonic development and in striated muscle gene expression. Our previous work has implicated a role for TEAD-1 in the fast-to-slow fiber-type transition in response to mechanical overload. To investigate whether TEAD-1 is a modulator of slow muscle gene expression in vivo, we developed transgenic mice expressing hemagglutinin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Kinetics
Share to Muscle Contraction

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Muscle, Skeletal

Share to Muscles

Share to RNA, Small Interfering

Share to Satellite Cells, Skeletal Muscle

Share to Stress, Mechanical

Share to Transgenes

Source

Open in PubMed Open full text

Identifiers

PMID: 18978355
DOI: 10.1074/jbc.M807461200
PMCID: PMC2606011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overexpression of TEAD-1 in transgenic mouse striated muscles produces a slower skeletal muscle contractile phenotype.PMID 18978355Read ↗

Transcription Enhancer Factor 1 Binds Multiple Muscle MEF2 and A/T-Rich Elements during Fast-to-Slow Skeletal Muscle Fiber Type TransitionsSemantic proximity Read ↗

Tropomyosin 3 expression leads to hypercontractility and attenuates myofilament length-dependent Ca(2+) activation.Semantic proximity Read ↗

Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers.Semantic proximity Read ↗

Contractile and metabolic properties of engineered skeletal muscle derived from slow and fast phenotype mouse muscle.Semantic proximity Read ↗

Muscle-Specific SIRT1 Gain-of-Function Increases Slow-Twitch Fibers and Ameliorates Pathophysiology in a Mouse Model of Duchenne Muscular DystrophySemantic proximity Read ↗

Lack of cyclin D3 induces skeletal muscle fiber-type shifting, increased endurance performance and hypermetabolism.Semantic proximity Read ↗

Coregulation of fast contractile protein transgene and glycolytic enzyme expression in mouse skeletal muscle.Semantic proximity Read ↗

Sorting of a nonmuscle tropomyosin to a novel cytoskeletal compartment in skeletal muscle results in muscular dystrophy.Semantic proximity Read ↗

NFATc1 controls skeletal muscle fiber type and is a negative regulator of MyoD activity.Semantic proximity Read ↗

Stimulation of Slow Skeletal Muscle Fiber Gene Expression by Calcineurin in VivoSemantic proximity Read ↗

TEAD transcription factors are required for normal primary myoblast differentiation in vitro and muscle regeneration in vivo.Semantic proximity Read ↗

De-phosphorylation of MyoD is linking nerve-evoked activity to fast myosin heavy chain expression in rodent adult skeletal muscle.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.