Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Desensitizing mouse cardiac troponin C to calcium converts slow muscle towards a fast muscle phenotype.

The Journal of physiology - 1 Oct 2018

Tikunova Svetlana, Belevych Natalya, Doan Kelly, Reiser Peter J

Abstract excerpt

KEY POINTS: The Ca2+ -desensitizing D73N mutation in slow skeletal/cardiac troponin C caused dilatated cardiomyopathy in mice, but the consequences of this mutation in skeletal muscle were not known. The D73N mutation led to a rightward shift in the force versus pCa (-log [Ca]) relationship in slow-twitch mouse fibres. The D73N mutation led to a rightward shift in the force-stimulation frequency relationship and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium
Share to Mice
Share to Mice, Inbred C57BL

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Muscle Contraction

Share to Muscle Fibers, Fast-Twitch

Share to Muscle Fibers, Slow-Twitch

Share to Muscle, Skeletal

Share to Troponin C

Source

Open in PubMed Open full text

Identifiers

PMID: 29992562
DOI: 10.1113/JP276296
PMCID: PMC6166084

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Desensitizing mouse cardiac troponin C to calcium converts slow muscle towards a fast muscle phenotype.PMID 29992562Read ↗

Mouse Models of Cardiomyopathies Caused by Mutations in Troponin C.Semantic proximity Read ↗

Differential effect of troponin T mutations on the inotropic responsiveness of mouse hearts--role of myofilament Ca2+ sensitivity increase.Semantic proximity Read ↗

Transgenic Mouse α- and β-Cardiac Myosins Containing the R403Q Mutation Show Isoform-dependent Transient Kinetic DifferencesSemantic proximity Read ↗

The effect of cardiomyopathy mutation (R97L) in mouse cardiac troponin T on the muscle length-mediated recruitment of crossbridges is modified divergently by α- and β-myosin heavy chain.Semantic proximity Read ↗

Mavacamten decreases maximal force and Ca2+ sensitivity in the N47K-myosin regulatory light chain mouse model of hypertrophic cardiomyopathy.Semantic proximity Read ↗

In Vivo Analysis of Troponin C Knock-In (A8V) Mice: Evidence that TNNC1 Is a Hypertrophic Cardiomyopathy Susceptibility Gene.Semantic proximity Read ↗

A dilated cardiomyopathy troponin C mutation lowers contractile force by reducing strong myosin-actin binding.Semantic proximity Read ↗

Hypertrophic cardiomyopathy-related β-myosin mutations cause highly variable calcium sensitivity with functional imbalances among individual muscle cellsSemantic proximity Read ↗

A lethal mutation in mice eliminates the slow calcium current in skeletal muscle cells.Semantic proximity Read ↗

Cardiomyopathy-related mutation (A30V) in mouse cardiac troponin T divergently alters the magnitude of stretch activation in α- and β-myosin heavy chain fibers.Semantic proximity Read ↗

Hypertrophic cardiomyopathy mutation in cardiac troponin T (R95H) attenuates length-dependent activation in guinea pig cardiac muscle fibers.Semantic proximity Read ↗

The dilated cardiomyopathy-causing mutation ACTC E361G in cardiac muscle myofibrils specifically abolishes modulation of Ca(2+) regulation by phosphorylation of troponin I.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.