Ca(2+) activation of myofilaments from transgenic mouse hearts expressing R92Q mutant cardiac troponin T.

doi:10.1152/ajpheart.2001.280.2.H705

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Ca(2+) activation of myofilaments from transgenic mouse hearts expressing R92Q mutant cardiac troponin T.

American journal of physiology. Heart and circulatory physiology - 1 Feb 2001

Chandra M, Rundell V L, Tardiff J C, Leinwand L A, De Tombe P P, Solaro R J

Abstract excerpt

The functional consequences of the R92Q mutation in cardiac troponin T (cTnT), linked to familial hypertrophic cardiomyopathy in humans, are not well understood. We have studied steady- and pre-steady-state mechanical activity of detergent-skinned fiber bundles from a transgenic (TG) mouse model in which 67% of the total cTnT in the heart was replaced by the R92Q mutant cTnT. TG fibers were more sensitive to...

Topics

Acidosis
Actin Cytoskeleton
Adenosine Triphosphate
Animals
Calcium
Cross-Linking Reagents
Detergents
Genes, myc
Humans
Mice
Mice, Transgenic
Muscle Contraction
Muscle Fibers, Skeletal
Mutation
Promoter Regions, Genetic

Source

Open in PubMed

Identifiers

PMID: 11158969
DOI: 10.1152/ajpheart.2001.280.2.H705

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Troponin T