Article

Absence of the Z-disc Protein α-actinin-3 Impairs the Mechanical Stability of Actn3KO Mouse Fast- twitch Muscle Fibres without Altering their Contractile Properties or Twitch Kinetics

2021-11-11

Abstract excerpt

<h4>Background: </h4> A common polymorphism (R577X) in the ACTN3 gene results in complete absence of the Z-disc protein α-actinin-3 from fast-twitch muscle fibres in ~16% of the world’s population. This single gene polymorphism has been subject to strong positive selection pressure during recent human evolution. Previously, using an Actn3KO mouse model, we have shown in fast-twitch muscles, eccentric contractions...

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Literature Corpus work: 660801b8-d497-5103-b128-68e95dabe90f
DOI: 10.21203/rs.3.rs-1062721/v1

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