Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypermuscular mice with mutation in the myostatin gene display altered calcium signalling.

The Journal of physiology - 15 Mar 2014

Bodnár Dóra, Geyer Nikolett, Ruzsnavszky Olga, Oláh Tamás, Hegyi Bence, Sztretye Mónika, Fodor János, Dienes Beatrix, Balogh Ágnes, Papp Zoltán, Szabó László, Müller Géza, Csernoch László, Szentesi Péter

Abstract excerpt

Myostatin, a member of the transforming growth factor β family, is a potent negative regulator of skeletal muscle growth, as myostatin-deficient mice show a great increase in muscle mass. Yet the physical performance of these animals is reduced. As an explanation for this, alterations in the steps in excitation-contraction coupling were hypothesized and tested for in mice with the 12 bp deletion in the propeptide...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium Signaling
Share to Evoked Potentials

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Membrane Potentials

Share to Mice, Inbred C57BL

Share to Mice, Mutant Strains

Share to Muscle Fibers, Skeletal

Share to Myostatin

Source

Open in PubMed Open full text

Identifiers

PMID: 24445322
DOI: 10.1113/jphysiol.2013.261958
PMCID: PMC3961092

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypermuscular mice with mutation in the myostatin gene display altered calcium signalling.PMID 24445322Read ↗

Lack of myostatin results in excessive muscle growth but impaired force generationSemantic proximity Read ↗

Exercise training attenuates the hypermuscular phenotype and restores skeletal muscle function in the myostatin null mouse.Semantic proximity Read ↗

A deletion in the myostatin gene causes the compact ( Cmpt ) hypermuscular mutation in miceSemantic proximity Read ↗

Myostatin knockout mice increase oxidative muscle phenotype as an adaptive response to exercise.Semantic proximity Read ↗

Myostatin is a key mediator between energy metabolism and endurance capacity of skeletal muscle.Semantic proximity Read ↗

The compact mutation of myostatin causes a glycolytic shift in the phenotype of fast skeletal muscles.Semantic proximity Read ↗

N2A Titin: Signaling Hub and Mechanical Switch in Skeletal Muscle.Semantic proximity Read ↗

SOCE Is Important for Maintaining Sarcoplasmic Calcium Content and Release in Skeletal Muscle Fibers.Semantic proximity Read ↗

Myostatin dysfunction is associated with reduction in overload induced hypertrophy of soleus muscle in mice.Semantic proximity Read ↗

The growth factor myostatin, a key regulator in skeletal muscle growth and homeostasis.Semantic proximity Read ↗

Defective regulation of contractile function in muscle fibres carrying an E41K beta-tropomyosin mutation.Semantic proximity Read ↗

Lack of functional caveolae in Cav3 mutated human dystrophic myotubes results in deficient mechanoprotection and IL6/STAT3 mechanosignalingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.