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Article

Myosin light chain kinase and myosin phosphorylation effect frequency-dependent potentiation of skeletal muscle contraction.

Proceedings of the National Academy of Sciences of the United States of America - 29 Nov 2005

Zhi Gang, Ryder Jeffrey W, Huang Jian, Ding Peiguo, Chen Yue, Zhao Yingming, Kamm Kristine E, Stull James T

Abstract excerpt

Repetitive stimulation potentiates contractile tension of fast-twitch skeletal muscle. We examined the role of myosin regulatory light chain (RLC) phosphorylation in this physiological response by ablating Ca(2+)/calmodulin-dependent skeletal muscle myosin light chain kinase (MLCK) gene expression. Western blot and quantitative-PCR showed that MLCK is expressed predominantly in fast-twitch skeletal muscle fibers...

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Identifiers

PMID: 16299103
DOI: 10.1073/pnas.0506846102
PMCID: PMC1297671

Genes

MYLK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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