Phenotypic Approaches to Identify Inhibitors of B Cell Activation.

doi:10.1177/1087057115585724

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Article

Phenotypic Approaches to Identify Inhibitors of B Cell Activation.

Journal of biomolecular screening - 1 Aug 2015

Rex Elizabeth B, Kim Suzie, Wiener Jake, Rao Navin L, Milla Marcos E, DiSepio Daniel

Abstract excerpt

An EPIC label-free phenotypic platform was developed to explore B cell receptor (BCR) and CD40R-mediated B cell activation. The phenotypic assay measured the association of RL non-Hodgkin's lymphoma B cells expressing lymphocyte function-associated antigen 1 (LFA-1) to intercellular adhesion molecule 1 (ICAM-1)-coated EPIC plates. Anti-IgM (immunoglobulin M) mediated BCR activation elicited a response that was...

Topics

Antibodies, Anti-Idiotypic
B-Lymphocytes
Calcium
Calcium Signaling
Cell Adhesion
Cell Adhesion Molecules
Cell Line
Drug Discovery
Humans
Immunosuppressive Agents
Inhibitory Concentration 50
Intercellular Adhesion Molecule-1
Lymphocyte Activation
Phenotype
Receptors, Antigen, B-Cell

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PMID: 25948491
DOI: 10.1177/1087057115585724
PMCID: PMC4512518

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