Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Importance of the N-distal AP-2 binding element in Nef for simian immunodeficiency virus replication and pathogenicity in rhesus macaques.

Journal of virology - 1 May 2006

Brenner Matthias, Münch Jan, Schindler Michael, Wildum Steffen, Stolte Nicole, Stahl-Hennig Christiane, Fuchs Dietmar, Mätz-Rensing Kerstin, Franz Monika, Heeney Jonathan, Ten Haaft Peter, Swigut Tomek, Hrecka Katarzyna, Skowronski Jacek, Kirchhoff Frank

Abstract excerpt

Point mutations in SIVmac239 Nef disrupting CD4 downmodulation and enhancement of virion infectivity attenuate viral replication in acutely infected rhesus macaques, but changes selected later in infection fully restore Nef function (A. J. Iafrate et al., J. Virol. 74:9836-9844, 2000). To further evaluate the relevance of these Nef functions for viral persistence and disease progression, we analyzed an SIVmac239...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Disease
Share to Adaptor Protein Complex 2

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Products, nef

Share to Lentivirus Infections

Share to Macaca mulatta

Share to Sequence Alignment

Share to Simian Immunodeficiency Virus

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 16611907
DOI: 10.1128/JVI.80.9.4469-4481.2006
PMCID: PMC1472002

Genes

CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Importance of the N-distal AP-2 binding element in Nef for simian immunodeficiency virus replication and pathogenicity in rhesus macaques.PMID 16611907Read ↗

Comprehensive analysis of nef functions selected in simian immunodeficiency virus-infected macaques.Semantic proximity Read ↗

Disrupting surfaces of nef required for downregulation of CD4 and for enhancement of virion infectivity attenuates simian immunodeficiency virus replication in vivo.Semantic proximity Read ↗

Negative factor from SIV binds to the catalytic subunit of the V-ATPase to internalize CD4 and to increase viral infectivity.Semantic proximity Read ↗

The Nef protein of primate lentivirusesSemantic proximity Read ↗

T-cell receptor:CD3 down-regulation is a selected in vivo function of simian immunodeficiency virus Nef but is not sufficient for effective viral replication in rhesus macaques.Semantic proximity Read ↗

Maintenance of AP-2-Dependent Functional Activities of Nef Restricts Pathways of Immune Escape from CD8 T Lymphocyte Responses.Semantic proximity Read ↗

Simian and human immunodeficiency virus Nef proteins use different surfaces to downregulate class I major histocompatibility complex antigen expression.Semantic proximity Read ↗

HIV-1 Nef disrupts intracellular trafficking of major histocompatibility complex class I, CD4, CD8, and CD28 by distinct pathways that share common elements.Semantic proximity Read ↗

A Truncated Form of Nef Selected during Pathogenic Reversion of Simian Immunodeficiency Virus SIVmac239Δnef Increases Viral ReplicationSemantic proximity Read ↗

Implication of the C-terminal domain of nef protein in the reversion to pathogenicity of attenuated SIVmacBK28-41 in macaques.Semantic proximity Read ↗

Conservation of Nef function across highly diverse lineages of SIVsmm.Semantic proximity Read ↗

Primary sooty mangabey simian immunodeficiency virus and human immunodeficiency virus type 2 nef alleles modulate cell surface expression of various human receptors and enhance viral infectivity and replication.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.