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Article

Nef genes of SIV.

Journal of medical primatology - 1 Jan 1990

Kestler H W, Mori K, Silva D P, Kodama T, King N W, Daniel M D, Desrosiers R C

Abstract excerpt

Molecular clones of SIVmac were constructed that differed only in sequences within the nef gene. DEAE-transfection of viral DNA containing an open from of nef yielded virus that replicated with similar kinetics and to a similar extent in macaque peripheral blood lymphocyte (PBL) cultures as virus with a deletion or stop codon within nef. Rhesus monkeys that received each kind of molecularly cloned virus became...

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Identifiers

PMID: 2231693

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nef genes of SIV.PMID 2231693Read ↗

The Nef protein of primate lentivirusesSemantic proximity Read ↗

Sequence diversity of SIV(Mne) Nef in vivo and in vitro.Semantic proximity Read ↗

A Truncated Form of Nef Selected during Pathogenic Reversion of Simian Immunodeficiency Virus SIVmac239Δnef Increases Viral ReplicationSemantic proximity Read ↗

The human immunodeficiency virus type 1 nef gene can to a large extent replace simian immunodeficiency virus nef in vivo.Semantic proximity Read ↗

Prolonged infection in rhesus macaques with simian immunodeficiency virus (SIVmac239) results in animal-specific and rarely tissue-specific selection of nef variants.Semantic proximity Read ↗

Disrupting surfaces of nef required for downregulation of CD4 and for enhancement of virion infectivity attenuates simian immunodeficiency virus replication in vivo.Semantic proximity Read ↗

Pathogenic Conversion of Live Attenuated Simian Immunodeficiency Virus Vaccines Is Associated with Expression of Truncated NefSemantic proximity Read ↗

Implication of the C-terminal domain of nef protein in the reversion to pathogenicity of attenuated SIVmacBK28-41 in macaques.Semantic proximity Read ↗

Nef gene evolution from a single transmitted strain in acute SIV infection.Semantic proximity Read ↗

In vitro studies of SIV nef functionSemantic proximity Read ↗

Interactions of HIV-1 NEF with cellular signal transducing proteinsSemantic proximity Read ↗

Protective Effects of a Live Attenuated SIV Vaccine with a Deletion in the <i>nef</i> GeneSemantic proximity Read ↗

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