Prolonged infection in rhesus macaques with simian immunodeficiency virus (SIVmac239) results in animal-specific and rarely tissue-specific selection of nef variants.

doi:10.1006/viro.1996.0342

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Article

Prolonged infection in rhesus macaques with simian immunodeficiency virus (SIVmac239) results in animal-specific and rarely tissue-specific selection of nef variants.

Virology - 15 Jun 1996

Zhu G W, Mukherjee S, Sahni M, Narayan O, Stephens E B

Abstract excerpt

We analyzed the sequence of nef genes from different tissues of three rhesus macaques that had been infected with molecularly cloned SIVmac239 for 88 to 92 weeks. Comparison of the predicted amino acid sequences revealed that each macaque had selected out specific amino acid substitutions and tha...

Topics

Amino Acid Sequence
Animals
Base Sequence
DNA, Viral
Gene Products, nef
Genetic Variation
Macaca mulatta
Molecular Sequence Data
Selection, Genetic
Simian Acquired Immunodeficiency Syndrome
Simian Immunodeficiency Virus

Source

Open in PubMed

Identifiers

PMID: 8661405
DOI: 10.1006/viro.1996.0342

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8661405-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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