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Article

Comprehensive analysis of nef functions selected in simian immunodeficiency virus-infected macaques.

Journal of virology - 1 Oct 2004

Schindler Michael, Münch Jan, Brenner Matthias, Stahl-Hennig Christiane, Skowronski Jacek, Kirchhoff Frank

Abstract excerpt

A variety of simian immunodeficiency virus (SIVmac) nef mutants have been investigated to clarify which in vitro Nef functions contribute to efficient viral replication and pathogenicity in rhesus macaques. Most of these nef alleles, however, were only functionally characterized for their ability to down-modulate CD4 and class I major histocompatibility complex (MHC-I) cell surface expression and to enhance SIV...

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Source

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Identifiers

PMID: 15367626
DOI: 10.1128/JVI.78.19.10588-10597.2004
PMCID: PMC516420

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Comprehensive analysis of nef functions selected in simian immunodeficiency virus-infected macaques.PMID 15367626Read ↗

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